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[13] In my opinion, methylation issues and the MTHFR gene variation can contribute to some of the symptoms commonly attributed to, or associated with, hypothyroidism

[30] Release of GSTs as an indication of organ damage [edit] The high intracellular concentrations of GSTs coupled with their cell-specific cellular distribution allows them to function as biomarkers for localising and monitoring injury to defined cell types

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Fat loss is the main contributor