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When combined with alpha-lipoic acid, some early research has shown that benfotiamine may enhance effects in reducing pain and improving nerve conduction in people with diabetic neuropathy.8 The synergy likely stems from their complementary mechanisms: benfotiamine helps manage glucose-induced damage, while ALA reduces oxidative stress and improves blood flow

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The sub-analysis builds on results previously presented at the American College of Cardiology (ACC) 2025 scientific session (2931 March, Chicago, USA) and published in The Lancet , demonstrating that semaglutide significantly improved walking outcomes in people with PAD and diabetes, enhanced quality of life, and reduced the risk of disease progression by 54%

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