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These key studies clearly provided clinical proof-of-concept that blocking the catalytic activity of DPP-4 could be a viable approach to treat T2DM, whilst at the same time helped to allay concern over whether the metabolism of any other potential DPP-4 substrates might be affected to cause unwanted off-target effects

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ADE was also observed for SARS-CoV and MERS-CoV in animal models 32,33,34,35,36,37

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Choi emphasizes that thinking about or reverting to how your body used to function before taking one of these medicines can feel demoralizing or like a step back, especially if it brought positive changes to your life

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