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This process is virtually painless and offers a quick and efficient way to deliver drugs into the systemic circulation

The final searches across all databases were conducted in December 2025 before manuscript submission, and no additional updates were performed thereafter

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In asthma, biologics such as dupilumab benefit from a more hierarchically organized type 2 signaling architecture in which IL-4R serves as a functionally convergent target, and validated biomarkers including blood eosinophils and FeNO enable precise patient stratification (45, 122)