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However, these changes only occurred in populations where lifestyle changes (in a healthy way) were also implemented and maintained once they stopped the medication
These effects occur through inhibition of NF-kappaB nuclear translocation and suppression of MAPK signaling pathway activation, reducing transcription of inflammatory mediator genes
They have potent anti-inflammatory and antioxidant activities
Additionally, apigenin appears to reduce the concentrations of pro-inflammatory cytokines, such as interferon gamma, interleukin 1A, and interleukin 12P70, by inhibiting nuclear factor-B signaling
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