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Month 1: the slow start that means everything Average weight loss: approximately 2 percent of body weight, with some trial participants losing up to 3.8 percent by week 4

Mazdutide typically reaches full dose around 8-12 weeks while Retatrutide may require 16-24 weeks for complete titration to maximum dose

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In December 2025, a separate multidistrict litigation grouping was created under the same federal judge for lawsuits alleging vision injuries