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In the SURMOUNT-1 trial, tirzepatide at higher doses achieved approximately 22% average body weight reduction, compared to approximately 16% with semaglutide at standard doses
It works primarily by reducing the amount of glucose your liver produces and improving how your body's cells respond to insulin
In some cases, they also recommend prescription weight-loss medication, counseling, or surgery
While Orlistat and Wegovy (semaglutide) operate through different mechanisms, theoretically offering complementary effects, there is no published clinical research directly studying their combined use
2020 Nov;11(6):1422-1425 20 1
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