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To view or add a comment, sign in First-pass metabolism (also called first-pass effect) is a pharmacokinetic phenomenon where the concentration of a drug is significantly reduced before it reaches systemic circulation
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Wu, Antifreezing hydrogel electrolyte with ternary hydrogen bonding for high-performance zinc-ion batteries
However, considering reopening the atelectatic alveolar could favor the selective vasodilatation of iNO, it is reasonable to combine pulmonary recruitment maneuvers (positive end-expiratory pressure (Johannigman et al., 2000), prone position ventilation (Germann et al., 1998), and high-frequency oscillation (Mehta et al., 2003)) with iNO to improve the gas exchange
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