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Epithelial cells are also separated from the extracellular matrix due to integrin disruption, causing -integrins to be relocated and viable cells to detach from the tubular basement membrane

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The trial tested multiple dose levels over 48 weeks, and the headline result, up to 24.2% body weight reduction at the highest dose, grabbed international attention

10.1681/ASN.2020091373 45 KishimotoA.DongS

Weeks 46 in informal reports : some community accounts describe early waist or body-fat changes, but other causes cannot be ruled out