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Statin-related myopathy has prompted interest in CoQ10 supplementation, as statins can reduce endogenous CoQ10 levels
Oxidative stress and inflammation can reinforce one another
Treatments for lipodystrophies are currently limited, and more effective therapies urgently needed (1)
Conversely, excessive NADPH accumulation can induce reductive stress, leading to the upregulation of NADPH oxidase 4 through activation of the PI3K/Akt signaling pathway, thereby promoting ROS generation, as observed in osteoarthritis (96)
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