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The post says biweekly or monthly dosing may become available as newer compounds advance, but that most GLP-1 therapy in clinical practice currently remains weekly
Insomnia from morning-dosed tesofensine indicates either excessive noradrenergic activation (resting HR above 85bpm is a clinical marker) or individual hypersensitivity to dopamine reuptake inhibition
But researchers are looking beyond neurons to study support cells such as glia and astrocytes that could aid appetite reduction
For example, the arousal score of the FSDS-DAO did not show a significant change, which rendered all secondary endpoints exploratory and p-values nominal
It acts on the glucagon receptor (GCGR) to increase energy expenditure and promote weight loss
