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Category 1 Bulk substance the FDA considers eligible for use in compounding pending final rulemaking Generally permitted Category 2 Bulk substance the FDA has significant safety, identity, or quality concerns about Not permitted during review Category 3 Substance requiring further evaluation Case-by-case Critically, Category 1 status is not FDA approval

In early 2026, HHS Secretary Robert F

Vitamin B12 injections are a highly effective treatment for addressing vitamin B12 deficiencies, improving energy levels, and supporting overall health

Prata JC, da Costa JP, Lopes I, Duarte AC, Rocha-Santos T