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The differences between the two groups, however, were not statistically significant

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Our results revealed marked serum lipid profile and electrolyte changes, declines in brain antioxidants and neurotransmitters (acetylcholine, dopamine, and serotonin levels) with elevations in thiobarbituric acid reactive substances and proinflammatory cytokine levels, as well as acetylcholinesterase and monoamine oxidase brain activity in TMX-treated rats

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These medications affect dopamine (happy chemical) release in the brain, altering reward pathway processes

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