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10.1126/science.287.5451.303 153 YinH.ChenQ

9 In some cases, symptoms associated with elevated vitamin B12 levels may actually occur in people undergoing treatment for a vitamin B12 deficiency rather than from excessive intake itself

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Sci Transl Med 9(385):eaak9679 He B et al (2018) Vascular targeting of LIGHT normalizes blood vessels in primary brain cancer and induces intratumoural high endothelial venules

For example, Robert's prostaglandin cytoprotection concept is still one of the most fascinating concepts in science development although not fully credited for ulcer healing, this may be particular to conceptual disagreements