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People with diabetes, particularly severe diabetes, tend to lose less weight with GLP-1s than people without diabetes, so microdosing is less likely to be as effective, though their dose should only be increased as they tolerate it. George said that in her professional opinion, microdosing is a potential option for patients with smaller amounts of weight to lose or as a bridge to start, or wean off, regular GLP-1 medications

Thats going to be most important bringing all disciplines to the table to discuss what to do with these medications and with future GLP-1s and combination GLP-1 medications that are going to be commercially available in the upcoming years. New Guidance to Come At this years Digestive Disease Week, Schulman told attendees that ASGE recruited a panel of experts to develop a Delphi position statement with expert panel consensus guidance. The team included seven gastroenterologists (including three bariatric endoscopists, one motility expert and three experts in guideline development/methodology), two endocrinologists and two anesthesiologists

This is why the reported effects are not just pigmentation