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Histopathology provided structural confirmation of these biochemical effects
42 Gastrointestinal autonomic neuropathy Gastrointestinal autonomic neuropathy affects the enteric nervous system, leading to dysregulation of gastrointestinal motility and function
Cominacini M, Valenti MT, Braggio M, et al
PT-141 was later developed as a selective derivative, removing the MC1R affinity to eliminate pigmentation while preserving the MC3R and MC4R activity responsible for sexual function modulation
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