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Cardiovascular Health B12 contributes to heart health through several mechanisms: Helps regulate homocysteine levels (a risk factor for heart disease) Supports red blood cell production for efficient oxygen transport Contributes to healthy blood vessel function Helps maintain proper nerve signals to the heart While not a primary treatment for heart conditions, optimal B12 levels support overall cardiovascular wellness
In addition, some other members of SIRTs including SIRT3, 4 and 5 display neuroprotective roles against epilepsy as a result of evidences supporting the improvement of neuronal damage for SIRT3 via scavenging ROS in mitochondria [120], protection from excitotoxicity for SIRT4 via increasing GLT-1-mediated glutamate uptake [121] and reduction of hippocampal neurodegeneration and attenuation of seizure susceptibility for SIRT5 [122]
Takeda T, Azumi J, Masaki M, Nagasawa T, Shimada Y, Aso H, et al
E.FrommJ
Mitochondrion 53 , 194202 (2020)
