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On territorial systems This contribution proposes a critical analysis of the acronyms and operational tools that describe the package of measures, actions and projects implemented with the resources allocated by the National Recovery and Resilience Plan (PNRR), the instrument through which the Next Generation EU European plan (the programme with which Europe responded to the pandemic crisis) was territorialised in Italy
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Toxic solvent residues DMF (dimethylformamide) Known liver toxin Associated with reproductive toxicity Must be removed to extremely low limits in GMP drugs DCM (dichloromethane / methylene chloride) Probable human carcinogen Central nervous system depressant Dangerous even in small amounts if injected TFA (trifluoroacetic acid) Corrosive Can remain in peptides as unmeasured TFA salt Pharmaceutical products often convert TFA salts to safer counterions Without validated HPLC, mass spectrometry, and residual solvent testing, patients may be injected with harmful chemical contaminants
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