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In practice, it seems better to tailor the choice to different patients, depending on the preference of the route of administration (oral vs injectable), the presence of intolerance or side-effects, and contraindications

doi: 10.1136/annrheumdis-2017-212763 69 LiotFBoval-BoizardBWeillDKuntzDWautierJL

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Patient safety and thorough clinical evaluation remain paramount when managing any new or unexplained symptoms during pharmacological treatment

These might include additive, synergistic, or antagonistic effects that cannot be reliably predicted without dedicated pharmacokinetic and pharmacodynamic studies