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Iron overload induces ferroptosis by activating Piezo1, a pressure-sensitive calcium channel in chondrocytes, leading to subsequent calcium inflow, which could be exacerbated by conditional GPX4 knockout in cartilage

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Long-term impact on total cost of care also remains to be seen. Employer groups are wondering if employees who are taking the drug for diabetes will be on them indefinitely, creating a costly, new, long-term budget concern with lingering questions about any savings from reductions in obesity-related illness

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