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Retatrutide, by contrast, remains in Phase 3 clinical development as of 2026
Slowed gastric emptying: One of the critical mechanisms of GLP-1 injections is their ability to slow down the emptying of the stomach
mild nausea
GIP(1-30)NH 2 is derived from the cleavage of the precursor protein pro-GIP by prohormone convertase 2 ( 2 activates the GIP receptor with equivalent potency and efficacy as GIP(1-42) and elicits the same physiological effects on glucose- and bone metabolism in humans ( 2 also acts as a substrate for DPP-4 ( Figure 1 )
& Jaenisch, R
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