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10.1371/journal.pone.0049121 39 HanV
2009 Mar Nazzareno Ballatori, Suzanne M Krance, Sylvia Notenboom, Shujie Shi, Kim Tieu, Christine L Hammond
Glutathione: * Protects LDL from oxidation * Reduces vascular inflammation * Supports nitric oxide function * Improves endothelial health * Assists mitochondrial ATP production * Detoxifies lipid peroxidation byproducts Cellular glutathione declines as we age after 20, and is further stressed in APOE4 carriers
Further, GLP-1RAs block the adhesion of monocytes to endothelium induced by oxidized LDL via extracellular signal-regulated kinase (ERK) 5-Kruppel-like factor (KLF)2 signaling pathway to prevent endothelial permeability [107, 108]
Many studies suggest that Tirzepatide, a dual GIP/GLP-1 receptor agonist, is the most effective among these options for weight reduction
