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Unlike the steatosis, clinical results about existing fibrosis are not satisfactory

In people with T2DM, the GIP response is enhanced [11], whereas the GLP-1 response is reduced compared to healthy people [12]

Continuous GLP-1RA use for three years was associated with the greatest reduction in MACE risk compared with sulfonylureas, whereas interruptions and discontinuations were associated with a progressive attenuation of this protective effect, with risk estimates in some scenarios approaching those of the comparator group