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and Lancha, A.H
doi:10.1038/ncomms4116
By combining all three receptor signals, triple agonists aim to reduce appetite (GLP1 and GIP), increase caloric burn (glucagon), and improve liver fat metabolism (glucagon)
Combination approaches that couple GSH-triggered release with ferroptosis induction, immunotherapy, radiotherapy, or metabolic modulation represent promising strategies to overcome resistance Fig
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