The possible sources are: (1) decreased expression and activity of cellular antioxidant systems (discussed above), or (2) increased production of ROS through major sources, such as mitochondria, that overcome the cellular antioxidant capacity, or (3) both
Statements Author contributions XPZ: Investigation, Writing original draft, Writing review & editing, Data curation, Supervision, Methodology, Software, Conceptualization, Resources, Visualization, Project administration, Formal analysis, Validation
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However, many of the studies are small and have methodological flaws, which makes it difficult to give firm guidance on this supplement or confirm its effects
[24] To decide whether NAC treatment is warranted, the RumackMatthew nomogram may be consulted