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The most common side effects are gastrointestinal: nausea (affecting ~25% of patients, usually mild and transient), diarrhea, constipation, and decreased appetite

Common side effects of semaglutide include: Digestive symptoms such as nausea, constipation, or diarrhea often improve within a couple of weeks after the last dose

Importantly, such variability does not negate biological relevance, but rather underscores the challenge of translating dynamic, context-sensitive endocrine signals into static biomarkers

For every point drop in hemoglobin A1C (HbA 1C ) patients can reduce their risk for microvascular complications by 40%