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Lancet Diabetes Endocrinol 6:605617 Mosenzon O, Blicher TM, Rosenlund S, Eriksson JW, Heller S, Hels OH et al (2019) Efficacy and safety of oral semaglutide in patients with type 2 diabetes and moderate renal impairment (PIONEER 5): a placebo-controlled, randomised, phase 3a trial
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Chemical modification of metformin into sulfenamides and sulfonamides has also improved the cellular accumulation of these compounds in cancer cells, with a subsequent increase in their cytotoxic efficacy
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