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217 Throughout the progression from precancerous lesions to localized tumors and from tumors in situ to metastatic tumors, the metabolic preferences of tumor cells continuously change in response to cellular states and environmental conditions, which are regulated by endogenous signals from tumor cells and signals from the tumor microenvironment

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Combines with dietary improvement in DIO mice to accelerate weight/fat loss and improve composition versus diet alone [3,4]

These are tiny, uncontrolled experiments, but they demonstrate how impacts can be marginal and diverse