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Long-term systemic use is concerning for copper balance, as copper deficiency has been linked to neurodegenerative disorders and even excess copper is risky

The Maintenance Trap: Why Most People Regain Post-GLP-1 Weight regain is generally expected when people discontinue taking GLP-1s

For instance, sineoculis homeobox homolog 1 (Six1) overexpression lifts GLUT3 expression in TC [53]

Those individuals may prefer the convenience of a once-weekly injection

GIP improves insulin sensitivity, may influence fat tissue metabolism directly, and appears to amplify the appetite-suppressing effects of GLP-1 in ways researchers are still mapping