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Macrophage-derived GSDMD plays an essential role in atherosclerosis and cross talk between macrophages via the mitochondria-STING-IRF3/NF-B axis
And the extended titration approach, maintaining each step for six weeks instead of four, dramatically improves tolerability for sensitive individuals
PubMed Central, Lee, Ho-Sun, et al
However, human clinical data on these wider applications are still preliminary
Cells 11 , 1284 (2022)
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