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This binding triggers a cascade of effects: delayed gastric emptying, reduced glucagon secretion, enhanced insulin sensitivity, and most importantly for weight loss, decreased food intake through central appetite suppression (Wilding et al., NEJM, 2021)
Common side effects are nausea, vomiting, abdominal discomfort, diarrhea and constipation
These changes resulted in the dismissal of three C-level executives, as well as 8,000 employees, as the company aimed to transform into a leaner organization
Research published in the journal Diabetes, Obesity and Metabolism confirms that GLP-1 receptor agonists reduce intestinal transit time through direct action on smooth muscle cells lining the gut wall
