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found that when GHRH was administered in a pulsatile fashion during the first half of the night, it significantly increased both GH levels and slow-wave sleep in healthy young men

Consequently, manipulating the effects of GLP-1 has been seen as having interesting potential as a therapeutic target in type 2 diabetes

Davies SJ (2011)

This extended duration is what allows it to be administered as a once-weekly injection

The body appears to adapt to both the delayed gastric emptying effects and the central nervous system appetite-suppressing signals, resulting in reduced nausea, vomiting, and other GI symptoms even as doses increase to therapeutic levels