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It is known that excess lipid accumulation in non-adipose tissues is associated with higher concentrations of NEFA and TAG in the circulation, and that this is often accompanied by inflammation, oxidative stress and cellular dysfunction or death ( Reference Mattern and Hardin 53 Reference Perez-Martinez, Perez-Jimenez and Lopez-Miranda 55 )
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Medications such as GLP-1 receptor agonists work best when used as part of a comprehensive, medically guided plan rather than as a stand-alone solution
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