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Biomarkers to monitor for GLP-1 safety Experts consider GLP-1s safe
Research presented at the 2025 American Academy of Orthopaedic Surgeons meeting found GLP-1 users had approximately 30% higher rates of osteoporosis compared to non-users, and a 2024 phase 2 trial published in eClinicalMedicine showed increased bone resorption markers and lower bone mass at the spine and hip in the semaglutide group versus placebo after 52 weeks
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Due to their preclinical testing and lack of comparison with other dual receptor agonists such as tirzepatide, further studies are needed to determine whether the effects of these unimolecular compounds are superior to those of clinically tested drugs
Inflammation markers drop
