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Participants received once-weekly injections of retatrutide at either the 9mg or 12mg dose, or a placebo, over 68 weeks

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Overexpression of SMAD2/3/4 improved, whereas overexpression of SMAD7 worsened obesity-associated metabolic syndromes in HFD-fed obese mice (Seong et al

Gastrointestinal adverse effects are common but generally manageable, allowing preservation of hepatic and cardiometabolic benefits