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This selective targeting underpins their efficacy in enhancing insulin secretion, inhibiting glucagon release, and promoting metabolic control in diabetes management (29)
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Think of it as opening the drainage valves on stored body fat
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GLP-1 can induce the expression of FNDC5 in pancreatic -cells through the interaction of its downstream transcription factor cAMP-response element binding protein (CREB) with binding elements in the FNDC5 promoter, thereby promoting the conversion of WAT to BAT and enhancing energy metabolism [85]
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