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Regarding liver and kidney damage in MTX treatment, Bedoui stated that MTX hepatotoxicity may occur due to the depletion of folate reserves and MTX-polyglutamate formation in the liver (Reference Bedoui, Guillot and Slambarom41)
When semaglutide therapy ends, appetite hormones rebound rapidlyoften within 3 to 7 daystriggering a return to baseline eating patterns and subsequent weight regain
The most common side effects, reported in at least 5% of people being treated with Ozempic in clinical trials of the drug, were: nausea vomiting diarrhea abdominal pain constipation These side effects were typically mild and became less bothersome with time
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