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These changes translate to reduced cardiovascular disease risk independent of weight loss effects

[8] Human pregnancy registries and population-based case-control studies demonstrate a dose-related elevation in the prevalence of cleft lip with or without cleft palate among infants exposed to topiramate monotherapy in the first trimester

The quality of the individual studies was assessed using the Cochrane risk of bias algorithm, and publication bias was assessed using funnel plot asymmetry

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Therefore, more clinical trials utilizing a large generalizable T2DM patient population with less influence from baseline characteristics and longer follow-up durations are needed to help guide clinical decision-making and reduce the burden of T2DM while also promoting cardiovascular health