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The accumulation of free radicals is one of the most important factors that accelerate this process
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Activation of aryl hydrocarbon receptor (AhR) in Alzheimers disease: role of tryptophan metabolites generated by gut host-microbiota
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However, it is important to note that erythrocytes generate ROS primarily as a result of (i) hemoglobin oxidation, which can be considered as an iron-mediated Fenton reaction, (ii) the activity of NAPDH oxidase and (iii) xanthine oxidoreductase, while in nucleated cells ROS are mainly generated in the mitochondrial electron transport chain
