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A systematic review and meta-analysis used to inform international PCOS guidelines discusses potential benefits and limitations (Fitz et al., 2024) in PubMeds record for the review
The body adapts to sustained lipolytic signaling
Doses greatly exceeding the nutritional requirements (for example, hundreds of milligrams daily) have not been studied in randomized trials for safety, so one should avoid mega doses in pregnancy unless treating a specific condition (such as pyridoxine-responsive seizures) under careful supervision
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