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According to the study, Doctors and reviews widely regard semaglutide (Wegovy) and tirzepatide (Zepbound/Mounjaro) as the top choices for achieving sustained, clinically meaningful weight loss (typically 1015%+ of body weight over 1218 months, alongside diet and exercise)
However, unintended weight loss in patients who are already at a healthy weight can be a concern and should be monitored
A trial of encapsulated glutamine, for example, failed to increase GLP-1 secretion in healthy participants or those with type 2 diabetes [47]
A critical aspect of their evaluation was determining whether patients had severe hypertriglyceridemia (HTG), defined as a triglyceride level above 500
