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These radicals are highly reactive causing lipid, DNA and protein oxidation eventually leading to the death of neurons in the dorsal root ganglia and the dentate nucleus of FRDA patients ( Polyunsaturated fatty acids (PUFAs) have been shown to be important for mitochondrial function, but are also very susceptible to oxidation, which can contribute to mitochondrial dysfunction (Tamarit et al., 2016)
Ridker, P
It guides treatment plans like blood transfusions and iron chelation therapy
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In order to enhance the clinical interpretation of these CVOTs, researchers have quantified the absolute treatment effect over time based on the number of treatments required to avoid a MACE, thus revealed the difference between GLP-1RA [175]
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