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NICE guidance (TA875) supports the use of semaglutide 2.4 mg (Wegovy) for adults with a BMI of 35 kg/m or above alongside at least one weight-related condition, within a specialist weight management service (with lower BMI thresholds applicable for certain ethnic groups and other commissioning criteria)

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Melanotan-II treatment improved sociability deficits in MIA mice MIA mice were treated with continuous 7-day intraventricular infusion of either MT-II or normal saline