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For the 670 randomized patients, at study entry (Week 0) mean body weight was 107.3 kg and mean BMI was 38.4 kg/m2, and at randomization (Week 36, after the open-label ZEPBOUND lead-in period) mean body weight was 85.2 kg and mean BMI was 30.5 kg/m2

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Thats why controlled trials are so crucial

However, the study concluded that taking these supplements doesnt significantly reduce body weight

Repeated semaglutide treatment attenuates cocaine-vs-food choice in male and female rats