For context, semaglutide (injectable) and tirzepatide (injectable) show much larger average losses in high-quality trials, but they are injectable prescription medicines with different mechanisms and risk profiles
Eric Topol's 2025 review of the peptide evidence described ipamorelin and related compounds as carrying 'the potential risk of cancer' on that mechanistic basis
Branded options are available, and Wegovy costs $1,400 a month and Zepbound $1,999 a month
What Testers Think Could Be Improved Transparent Labs creatine isnt the most budget-friendly on our list (if youre looking for a cheaper option, we recommend Nutricost Micronized Creatine Monohydrate) but given the third-party testing and clean formulation, we think its well worth the investment
Volcano plots of the fold change in mitochondrial metabolite abundance (log 2 ) vs P values (-log) from HEK-293T SLC25A39 knockout cell line expressing a vector control or SLC25A40 cDNA