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The roles of glutathione, glutathione peroxidase, glutathione reductase and the carbonyl protein in pulmonary and extra pulmonary tuberculosis
Similarly, urate is also neuroprotective by enhancing GSH expression through activation of the Akt/GSK3/NRF2/GCLC pathway in mutant SOD1 G85R cellular and Drosophila models (Zhang et al., 2019b)
Abdel-Motaleb AA, Bakr RM
This supports a model in which CHAC1-mediated GSH depletion destabilizes NRF2 and reduces cystine import, allowing iron-dependent lipid peroxides to accumulate and trigger ferroptosis
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