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Studies have suggested that Nrf2 is activated in the joints of arthritic mice and patients with rheumatoid arthritis, whereas Nrf2 deficiency is associated with accelerated arthritis development 44,45 , suggesting that Nrf2 might be a potential therapeutic target for OA

Transfer of CD8 + cells induces localized hair loss whereas CD4+/CD25 cells promote systemic alopecia areata and CD4+/CD25 + cells blockade disease onset in the C3H/HeJ mouse model

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