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JAMA - J Am Med Assoc 316(5):500508
Neuroprotective properties of nitric oxide and S-nitrosoglutathione
In LOsG-induced prediabetes, although pancreatic ROS stress remained high on LOsG treatment day 38, there were no alterations in mRNA levels of ER stress (XBP1 and BIP), inflammation (IL6 and IL1), and hypoxia-responsive (HIF1 and GAPDH) genes between LOsG- and sham-treated groups
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Though modest, it was statistically significant, reinforcing that GLP-1 RAs provide cardiovascular benefit even in a broad diabetes population
