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Lancet 398 , 21602172 (2021)

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A 5 to 8 minute plasma half-life means that by the time subcutaneously injected DSIP is absorbed from the injection site, cleared through lymphatics into venous blood, and circulated, a very substantial fraction has already been enzymatically degraded

[Russian language source] Nasonov EL, et al

NAD+ therapy replenishes levels for improved quality of life