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GLP-1R agonists may exert antidepressant effects by modulating inflammatory processes in the brain Chronic inflammatory processes in the brain associated with excessive activation of microglia and increased production of pro-inflammatory cytokines are one of the key factors leading to the development of depressive symptoms, as patients suffering from this mental illness are very often characterized by elevated levels of tumor necrosis factor-alpha (TNF-), interleukin-6 (IL-6), interleukin-1 beta (IL-1), C-reactive protein (CRP), and interferon-gamma (IFN-) in the cerebrospinal fluid and the blood [59,60,61]

Mounjaro vs Semaglutide Clinical research consistently shows tirzepatide-based medications like Mounjaro produce greater average weight loss than semaglutide-based medications

Atorvastatin induces mitochondria-dependent ferroptosis via the modulation of nrf2-xCT/GPx4 Axis

Idris I, Patiag D, Gray S, Donnelly R

All UK pharmacies and prescribers must be properly regulated (GPhC, GMC, CQC registered)